Neurotransmitter excitatory amino acids in synovial fluids demonstrate distinct temporal fluctuations in active arthritis
نویسندگان
چکیده
منابع مشابه
Excitatory amino acids display compartmental disparity between plasma and synovial fluid in clinical arthropathies.
BACKGROUND Previous studies have demonstrated elevated levels of excitatory amino acids (EAA) glutamate (Glu) and aspartate (Asp) in the synovial fluid (SF) of patients with active arthritis. The source of SF EAA concentrations are thought in large part to be secondary to passive diffusion from the plasma across synovial membranes and less so, reflective of local synovial pathology. OBJECTIVE...
متن کاملDistinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.
Intracellular recordings were made from neurons of rat lateral amygdala, nucleus accumbens, and striatum in vitro. Synaptic potentials mediated by gamma-aminobutyric acid and by excitatory amino acids were isolated pharmacologically by using receptor antagonists, and their amplitudes were used as a measure of transmitter release. Muscarine and acetylcholine inhibited the release of both gamma-a...
متن کاملComplement system in synovial fluids from patients with rheumatoid arthritis.
Immunological processes have been thought to play a role in rheumatoid arthritis, but no conclusive evidence has yet been obtained. Rheumatoid factor (RA factor) is known to be an antibody-like protein frequently found in the sera of patients with rheumatoid arthritis, but it has not been proved that it has any immediate relationship with the inflammatory processes of the disease, and the speci...
متن کاملT cell derived cytokines in psoriatic arthritis synovial fluids.
OBJECTIVE The aim of this study was to investigate the concentrations of T cell derived cytokines in the synovial fluids (SFs) of patients with psoriatic arthritis (PsA) in comparison with rheumatoid arthritis (RA) and osteoarthritis (OA). METHODS Th1 type cytokines (interleukin 2 (IL2), tumour necrosis factor beta (TNF beta), and interferon gamma (INF gamma) and Th2 type cytokines (IL4, IL10...
متن کاملExcitatory amino acids and Parkinson's disease.
SIR: Recently, Klockgether and Turski proposed that antagonists of excitatory amino acids may be beneficial in the treatment of Parkinson's disease 1. This suggestion , previously put torward by others 2-4, is supported by recent findings of animal experiments as weil as by clinical data. On the basis of these findings, a somewhat different conclusion can be drawn about the role of gluta-mate i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Rheumatology and Orthopedic Medicine
سال: 2018
ISSN: 2399-7370
DOI: 10.15761/rom.1000161